Cool It

Cool it.

Holding the inflammatory system in check: NLRs keep it cool

Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repair and resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central to several diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovascular disease. This report aims to review the literature regarding several members of the nu...

Fever in sepsis: is it cool to be hot?

Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infection associated with very high mortality. Combined with recent data suggesting that febrile patients with infections have the lowest mortality risk, the study raises the question of wh...

Lower Dialysate Temperature in Hemodialysis: Is It a Cool Idea?

Vascular instability and severe episodes of intradialytic hypotension (IDH) represent the most frequent (up to 20%) (1) and challenging complications of conventional dialysis regimens (2), resulting in underdialysis and volume expansion (3). In addition, repeated episodes of IDH are uncomfortable for the patient and may causemultisystemmorbidity and increased risk of mortality (3). These advers...

'Cool', Brands and 'Cool' Brands

The term ‘cool’ is widely used expression in popular culture. This word is prefixed liberally with anything including people, behavior, place and brands. Notwithstanding ambiguity about what it stands there is complete clarity that it certainly adds value. ‘Cool’ in this perspective is precious resource which can be used in brand building. The authors’ exploration into its genesis and meaning r...